Anti-endometrial antibodies (EMAb) are autoantibodies that target the endometrium as a target antigen and cause a series of immune responses. It has been reported that the positive rate of anti-endometrial antibodies in the blood of endometriosis and infertile women is significantly higher than that of normal controls. Among the serum of endometriosis, the detection rate of EMAb is up to 70%-80%. Clinical studies have shown that the ectopic endometrium is antigenic and induces the body to produce anti-endometrial antibodies.
Generation
Anti-endometrial antibodies (EMAb) are produced in two ways: on the one hand because of the ectopic endometrial stimulation system; on the other hand, on the body's immune system disorders (autoimmune defects).
Antibody infertility
The normal body has autoimmune regulation function, which produces extremely weak autoantibodies, which helps to eliminate the auto component of aging and degeneration in the body. Once the immune system has an excessive immune response to its own tissue for some reason, a series of immune reactions will occur. , resulting in increased tissue immunocompetent cells, immune complex deposition, resulting in functional changes.
The immune concept of infertility caused by anti-endometrial antibodies is a relative concept, which means that immunity reduces fertility and temporarily leads to infertility. Whether infertility can continue depends on the interaction between immunity and fertility. If immunity is stronger than fertility, infertility occurs. If the latter is stronger than the former, pregnancy occurs. Infertility often has multiple factors at the same time, and immune factors can also be the sole cause of infertility or coexist with other causes.
Chinese treatment
Chinese doctor believes that this disease is mainly caused by kidney deficiency, involving liver blood deficiency, liver stagnation, which is more common in kidney yin deficiency. The damp heat accumulates under the coke, and the heat disturbs the testis or the heat cell, so that the embryo cannot be successfully bred.
The treatment of this disease is related to promoting blood circulation, improving microcirculation, improving immunity and inhibiting antibody production. After clinical treatment and verification, the symptom and sign relief rate after treatment according to this type can reach more than 80%.
Cause
The immune system of human being is an extremely complex system that plays an important role in maintaining the homeostasis and health of the body. The immune system has three main functions, namely, resisting the invasion of foreign pathogenic microorganisms, clearing the cells of aging and dying, and identifying and clearing the mutated cells, thus being an indispensable physiological defense mechanism for maintaining the stability of the body environment.
When the immune system's defense function is abnormal, it will lead to a series of immunopathological processes, such as infection, immunodeficiency, autoimmune diseases and tumors, which may also cause obstacles in the reproductive process. Generally, self-organized tissue does not become an antigen, but in some cases, antibodies, such as infection, retrograde blood flow, cauterization, or drug action, can cause denaturation of proteins in tissue cells to become autoantigens. Blood circulation stimulates the body to produce an immune response.
Anti-endometrial antibodies are autoantibodies and can be detected in normal women of childbearing age, but are more common in infertile people, especially in women with endometriosis.
Clinical studies have shown that the ectopic endometrium is antigenic and induces the body to produce anti-endometrial antibodies. When the antigen-antibody binds, it can be deposited in the endometrium and ectopic lesions, destroying the endometrial structure by activating complement.
Since anti-endometrial antibodies are produced in large amounts due to repeated stimulation, antigen-antibody binding reaction can occur with their own endometrial tissues, and the immune system is activated to cause damaging effects, resulting in endometrial tissue cell biochemical metabolism and Damage to physiological function.
The ectopic endometrium is antigenic and induces the body to produce anti-endometrial antibodies. The occurrence of anti-endometrial antibodies leads to infertility, pregnancy or abortion.
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